December 6, 2013
Ever since Dr. Oz quoted SanMedica’s HGH study, the world can’t stop talking about SeroVital.
“I have found the fountain of youth via Dr. Oz,” says Ronald Reavis on Facebook. “It’s called SeroVital HGH.”
“I talked to a reporter about a new supplement I’m taking, SeroVital,” adds Kevin James Bennett, celebrity Makeup Artist. “The stuff is working for me – end of story.”
Supposedly SeroVital is designed to increase HGH levels by as much as 682% without the need for expensive prescription injections.
Yet despite its glowing reputation, I can’t help but question the product. Does it deserve its time in the spotlight?
ALSO RECOMMENDED: Click Here to See the Top-Rated HGH Supplements of the Year
What’s In the Formula?
SeroVital is formulated with amino acids specifically chosen to stimulate the pituitary gland and increase HGH production:
L-Lysine HCI. Lysine is essential for protein production and boosting immunity. It is often used to improve athletic performance.
Studies show lysine, when combined with arginine, provokes, “a release of pituitary somatotropin (HGH) and insulin.” However, consumers should note the study featured 1200 mg of both lysine and arginine. 
SeroVital.com does not list specific ingredient concentrations, so it’s impossible to tell if it contains this amount. Assuming SeroVital is much like Growth Factor 9 (a performance enhancer that utilizes SeroVital), then chances are likely that formula only contains 2.9 grams in the entire blend. This is not enough to contain clinically proven amounts of each ingredient.
L-Arginine HCI. Arginine is essential for nitric oxide production, a compound which relaxes blood vessels and improves blood circulation.
According to researchers, “resting growth hormone responses increase with oral ingestion of L-arginine.” 
But, once again, arginine should be taken in 5-9 g doses –more than double the amount found in SeroVital.
Oxo-Proline. Oxo-proline is derived from glutamic acid.
Interestingly enough, animal studies suggest oxo-proline “causes protein oxidation and reactive species production and decrease the non-enzymatic antioxidant defenses in the brain.” 
So what does this mean for you?
Oxo-proline may “elicit oxidative stress,” or an imbalance between reactive oxygen and the body’s ability to repair the resulting damage. It creates toxic effects via the free radical production.
In a nutshell, supplementing with this amino acid may damage all cell components including proteins, lipids, and DNA.
Not exactly comforting is it?
N-Acetyl L Cysteine. Cysteine functions as a potent antioxidant. First, it binds to and neutralizes free radicals. Then, it promotes the synthesis of an endogenous antioxidant glutathione. NAC is a more stable cysteine form which can be converted to cysteine in the cell.
While NAC may be useful for counteracting oxo-proline’s oxidative effects, there is not enough research to confirm any impact on HGH production.
L-Glutamine. This amino acid acts as a buffer during exercise, preventing muscle catabolism and muscle soreness.
Studies show HGH preserves muscle-free glutamine stores, increasing the body’s ability to work harder for longer. 
However, there is not enough information to suggest glutamine supplementation increases HGH production.
Schizonepeta (Aerial Parts). Schizonepeta is the scientific name for the Japenese Catnip. This herb may inhibit histamine and cytokine release, making a potential treatment for allergic reactions. 
But once again, there are not clinical studies on schizonepeta’s effects on HGH.
Where’s the Research?
SeroVital manufacturers like to quote a 2012 study featuring “more than 500 of the most highly respected scientists from around the globe.” The study was presented and discussed at the Obesity Society’s 30th Annual Scientific meeting.
According to the study, the orally administered compound was “capable of increasing mean serum (blood) growth hormone levels by 682%.”
Sounds pretty convincing right?
For such a groundbreaking discovery, I can’t help but question its validity. If SeroVital could really increase HGH that dramatically, wouldn’t the study be published in a peer-reviewed journal?
Yet for all my searching, I can’t find the study anywhere online.
Secondly, I don’t know the exact ingredient concentrations in either the study or the formula. This means it’s impossible to tell if SeroVital produces the same results as the compound found in the study.
Furthermore, I don’t know who sponsored the study. Did SeroVital manufacturers create the study specifically to sell the product? Were the results slanted in the product’s favor?
Until more of my questions are answered, I’m not convinced SeroVital is as incredible as everyone seems to believe.
How Does It Compare to HGH Injections?
According to Dr. Peter Griffiths, author of How to Burn More Fat 24 Hours a Day. . .Without Diet or Exercise:
“Even if this product works as claimed, their own study admits it is equivalent to 0.06iu of injected GH, a dose which anyone who has used real injected GH will tell you has virtually no fat loss effects.”
Despite the hype and celebrity endorsement, SeroVital does not come close to HGH injections in terms of optimizing HGH levels and physical performance.
What’s the Connection Between Growth Factor 9 and SeroVital?
Growth Factor 9 is an HGH boosting supplement that contains SeroVital’s formula.
According to a recent report:
“With all the recent media coverage, sales have gone through the roof and our suppliers have been having trouble keeping up . . . So we’re thrilled to announce that we’ve recently issued a … license to sports supplement company Novex Biotech, which will sell the compound as Growth Factor-9 exclusively at GNC. . .This will give consumers an extra avenue to get their hands on our proprietary formula.” 
Potential Risks and Side Effects
SeroVital does not contain harsh stimulants such as caffeine or ephedra to improve your performance. In fact, many of the ingredients can naturally be found in your regular diet and are considered safe to use on a regular basis.
However, I am a little concerned about the proprietary blend. Some ingredients such as arginine are safe when used in correct amounts. Too much arginine may result in abdominal pain, bloating, diarrhea, gout, and even low blood pressure.
Furthermore, there are several ingredients that are not fully studied. Human trials need to be conducted to ensure safety and efficacy.
If you are currently taking medication, consult your doctor before using SeroVital to ensure none of the ingredients will react negatively.
How to Use SeroVital
SeroVital should be taken on an empty stomach in order to enhance absorption. Optimum times would be first thing in the morning, at least two hours before you eat breakfast (or any other meal), or before bed, at least two hours after your last meal.
Do not take more than 4 capsules within a 24 hour time period.
What Consumers Are Saying
SeroVital is becoming more and more popular due to celebrity endorsement.
Kevin James Bennett, celebrity and runway makeup artist, shared this experience with a Radar reporter.
“I wasn’t expecting a visible change in my appearance from SeroVital, much less one that has been noticed by others,” he says. “I’m over 50-years-old and after 4 weeks on SeroVital I was being asked, by numerous people, what I was doing to my skin. Seriously? People in my industry were commenting about how great my skin looked.” 
With Kevin’s endorsement, it’s no wonder consumers are flocking to the product. . .
“I’ve been using this product for 2-3 months now. I notice and increase of energy, cleaner and better looking skin,” says Raymond Risk, a SeroVital user at Facebook.com. “’m going to continue to use this supplement for awhile longer.”
While SeroVital seems like a great way to improve skin, many consumers have yet to experience the promised muscle growth and fat loss.
“i also am an avid gym user and haven’t notice much for muscle growth yet,” continues Raymond. “I haven’t heard anything about people gaining strength or size in muscle just beauty facts. whats the deal?”
Does Dr. Oz Recommend SeroVital?
Dr. Oz’s name has been tossed around from product to product in hopes of lending credibility and popularity.
However, consumers should know that Dr. Oz never endorses a specific product.
“I am not and have never been a paid spokesperson for any particular brand, supplement or product,” states Dr. Oz. “Because so many merchants are using my name and image to sell their products, it’s hard for me to catch everything.” 
While many SeroVital advertisers like to mention his “Recharge Your Body in 5 Ways in 5 Days!” episode consumers should note his exact words:
“A recent study showed that patients given a special blend of amino acids saw their HGH levels spike more than 6 times the levels they had at the beginning of the study.” 
Although Dr. Oz did quote a study similar to SeroVital’s, he did not mention SeroVital specifically in the show.
Where to Buy SeroVital
If you want to buy SeroVital directly from the manufacturers, go to SeroVital.com and buy a bottle for $99.
You can also sign up for a preferred customer plan where “future orders of SeroVital will be automatically billed and shipped every 30 days for just $80, including shipping and handling.”
But, for many customers, even this discounted price is too much to afford.
SeroVital is available through various distributors (and under different brand names), but even if you shop around, the price will still be high.
• Ulta.com: $99 (SeroVital)
• NovexBiotech.com: $99 (Growth Factor 9)
• GNC.com: $99.99 (Growth Factor 9)
• eVitamins.com: $99.99 (Growth Factor 9)
• LuckyVitamin.com: $99.99 (Growth Factor 9)
Is There a Guarantee?
SeroVital.com has an impressive-looking image of a 100% money-back guarantee. However, the terms and conditions of this guarantee are unknown as they are not specified on the website.
If you are not satisfied with SeroVital, then you may contact customer service by filling out an email form provided on the site or by calling 800-435-1409.
Who Makes SeroVital?
SeroVital is owned and distributed by SanMedica International.
According to Chantelle Daines, Media Consultant for Sanmedica, “We’re thrilled with the response we’ve gotten since the Dr. Oz . . .We just hope customers will accept our sincere apologies for the shortages and continue to be patient as we ramp up production.” 
However, the formula itself was developed by the Sierra Research Group LLC, a company located in Salt Lake City.
Not a lot is known about Sierra Research Group, with the exception of a few news posts listed on the website.
According to the Division of Corporations and Commercial Code, Sierra Research Group is held in “good standing.” However, there is not enough information to know how long the company has been researching supplements or if it provides reliable products.
Should You Try SeroVital?
While many users love their results with SeroVital, I’m not particularly impressed.
The ingredients are little more than amino acids, which are commonly found in natural foods. Many ingredients lack clinical studies to confirm any positive effects on HGH. The one study that may show promise is not published and available to the public. Then to top it off, the concentrations are hidden behind a proprietary blend.
When you add on the hefty price tag with a questionable guarantee, SeroVital seems to be more risky than it’s worth.
But what do you think? Have you tried SeroVital?
 Isidori A, Lo Monaco A, Cappa M. “A study of growth hormone release in man after oral administration of amino acids.” Curr Med Res Opin. 1981;7(7):475-81. Available from: http://www.ncbi.nlm.nih.gov/pubmed/6790230
 Kanaley JA. “Growth hormone, arginine and exercise.” Curr Opin Clin Nutr Metab Care. 2008 Jan;11(1):50-4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18090659
 Carolina D Pederzolli, Angela M Sgaravatti, César A Braum, Cristina C Prestes, Giovanni K Zorzi, Mirian B Sgarbi, Angela T S Wyse, Clóvis M D Wannmacher, Moacir Wajner, Carlos S Dutra-Filho. “5-Oxoproline reduces non-enzymatic antioxidant defenses in vitro in rat brain.” Metabolic Brain Disease (impact factor: 2.2). 04/2007; 22(1):51-65. DOI:10.1007/s11011-006-9041-2 Available from: http://www.researchgate.net/publication/6565054_5-Oxoproline_reduces_non-enzymatic_antioxidant_defenses_in_vitro_in_rat_brain
 F Hammarqvist, C Strömberg, A von der Decken, E Vinnars, and J Wernerman. “Biosynthetic human growth hormone preserves both muscle protein synthesis and the decrease in muscle-free glutamine, and improves whole-body nitrogen economy after operation.” Ann Surg. 1992 August; 216(2): 184–191. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1242590/
 Kang, H; Oh, YJ; Choi, HY; Ham, IH; Bae, HS; Kim, SH; Ahn, KS (2008). “Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro”. The Journal of pharmacy and pharmacology 60 (7): 901–7. doi:10.1211/jpp.60.7.0012. Available from: http://www.ncbi.nlm.nih.gov/pubmed/18549677
 Johnsen, Michael. “Sierra Ressarch Labs licenses distribution of SeroVital-hgh through GNC to Novex Biotech.” Drug Store News. Dec 27, 2012. Available from: http://drugstorenews.com/article/sierra-research-labs-licenses-distribution-serovital-hgh-through-gnc-novex-biotech
 “Celebrity Makeup Artist Reveals His Anti-Aging Secret.” Radar Online. Feb. 5, 2013. Available from: http://radaronline.com/exclusives/2013/02/celebrity-makeup-artist-reveals-his-anti-aging-secret/
 Oz, Mehmet. “My Name for Profit? Not Anymore.” The Dr. Oz Show. Available from: http://www.doctoroz.com/blog/mehmet-oz-md/my-name-profit-not-anymore
 Oz, Mehmet. “Recharge Your Body in 5 Ways in 5 Days!” The Dr. Oz Show. Available from: http://www.doctoroz.com/episode/recharge-your-body-5-ways-5-days?video=15367
 “Revolutionary ‘Anti-Aging’ Compound Touted by Dr. Oz.” Red Orbit. Nov 16, 2012. Available from: http://www.redorbit.com/news/health/1112733120/revolutionary-antiaging-compound-touted-by-dr-oz/